Preparation of Anti Cancer Drug Candidate by One-Step Esterification of MWNTS with Derivatives of 4-Hydroxy-2-Nitrophenylimino-Indolin-2-One

Nowadays, cancer is one of the main reasons of death between nations caused by different elements such as presence of mutagenic and cancer causing materials in the environment. Isatin and Carbon nanotubes can be used to deliver their cargoes to cells and organs. The potential use of them to treat several types of cancer, with minimal or no toxic effects to normal cells. In the present study, 1,4-diazabicyclo [2.2.2] octane (DABCO) was used as a catalyst for one-pot reaction. Three-component condensation reactions consisting of isatin or bromo-isatin, 4-amino-3-nitrophenol and MWNTCOOH in hot water under mild conditions at 85°C, to afford the corresponding MWNTCO-4-hydroxy-2-nitrophenylimino-indolin-2-one derivatives. This method has the advantages of a simple operation and mild reaction conditions, by using low cost chemical as a catalyst. Products have been investigated by FT-IR, Raman, SEM, TEM and Ultra Violent spectroscopy. Biological activity with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.